Jan. Reviews

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Dr. Osama K Zaki                    

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Jan. Reviews

 

FOR IMMEDIATE RELEASE

Reviews of Literature

By Dr. Osama Zaki

January,15,2001 -- The following is a brief list of the most recent publications that came to our attention during the last months.  To read  the topics or their abstracts, just click the underlined link.

Gene and Stem Cell Therapies - JAMA
Gene and stem cell therapies hold promise for the treatment of a wide variety of inherited and acquired human diseases. Identification of genes involved in human disease and development of novel vectors and devices for delivering therapeutic genes to different tissues in vivo have resulted in significant progress in the area of gene therapy...
Genetic Information, Genomic Technologies, and the Future of Drug Discovery - JAMA
The completion of the first draft of the human genome has provided an unprecedented opportunity to understand the genetic and molecular basis of disease...
Implications of the Human Genome Project for Medical Science - JAMA
The year 2000 marked both the start of the new millennium and the announcement that the vast majority of the human genome had been sequenced. Much work remains to understand how this "instruction book for human biology" carries out its multitudes of functions. But the consequences for the practice of medicine are likely to be profound...

 

Orbital involvement in cherubism - Clinical and Experimental Ophthalmology
Cherubism is a rare, inherited condition characterized by fibro-osseous lesions of the maxilla and mandible. It has recently been localized to chromosome 4p16.3. The fullness of the lower half of the face and retraction of the lower lids gives the characteristic ‘eyes raised to heaven’ cherubic appearance...
Three-dimensional MR microscopy of a transgenic mouse model of dilated cardiomyopathy - Pediatric Radiology
Scientists are now able to alter the genetics of vertebrate embryos routinely to produce animal models of human developmental diseases...
Apoptosis in neuroblastomas induced by interferon-gamma involves the CD95/CD95L pathway - Medical & Pediatric Oncology
The CD95/CD95 ligand (CD95L) system is a key regulator of apoptosis. To evaluate a possible role of the CD95/CD95L system in human neuroblastoma (NB) cells, we investigated the constitutive and interferon (INF)-induced expression of CD95 and CD95L, and CD95-mediated cell death in the SK-N-BE(2) cell line...
Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1 - Medical & Pediatric Oncology
Neuroblastoma shows remarkable heterogeneity, resulting in favorable and unfavorable outcomes. It is well known that almost all cases with MYCN amplification have a poor prognosis...
DR-nm23 expression affects neuroblastoma cell differentiation, integrin expression, and adhesion characteristics - Medical & Pediatric Oncology
Nm23 gene family has been associated with metastasis suppression and differentiation. We studied DR-nm23 during neuroblastoma cells differentiation. DR-nm23 expression increased after retinoic acid induction of differentiation in human cell lines SK-N-SH and LAN-5...
IGFBPs are involved in xenograft development in nude mice - Medical & Pediatric Oncology
The insulin-like growth factors (IGFs) are involved in the growth and differentiation of neuroblastoma cells. In all biological fluids, they are non-covalently bound to high-affinity binding proteins (IGFBP-1 to -6) which modulate their bioavailability...

Your contribution with new items, local or international publications will be a great addition to this page. to send a paper or other information please contact us

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